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KMID : 0667720000370000407
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Report Natlonal Institute of Health
2000 Volume.37 No. 0 p.407 ~ p.408
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Biochemical and Molecular Changes in reponse to environmental hormones
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Abstract
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The interest in the environmental hormones was firstly started when zoologists found the abnormal reproduction and endocrine phenomena, and now expanded to the human. Many synthetic chemicals during industralization were known to affect the disruption of endocrine system of not only animals but also human as well. This vicious actions resulted in the decrease in number of sperm and penis size and even womanization (sexual reversal, and finally extermination of a stock. Since physiological hormones do work various functions and effects on biological bodies, environmental hormones are also likely to affect the thalamus-pituitary gland-sex hormone axes, the production, secretion, transport, disintegration and signaling actions of normal physiological hormones. This review concerns with general phenomena (pathophysiology on animal and human bodies) of environmental hormones, and moreover describes specific mechanism of biochemical and molecular biological actions on cell toxicity and cancer. However, readers should understand there are many other mechanisms of environmental hormones besides its mechanism described here.
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